mTOR inhibitor

Youth & Earth : Preservage

We cannot stress enough the importance of taking care of your body from the inside out and new supplements always pique our interest. At The Amazing Blog, we’re constantly reading up on ‘biohacking’ and were thrilled to test Preservage from the award-winning Youth & Earth, where it recently won ‘Best Wellbeing Brand’ and ‘Best Supplement - Age Well’ at the 2022 Beauty Shortlist Wellbeing Awards.

Youth & Earth is a British brand that produces natural anti-ageing supplements, using cutting edge science to slow down ageing at a cellular level. Although life expectancy has been increasing in the UK for the past few decades; there has been a slowdown over the last decade. There are ‘Blue Zones’, which are geographic areas where people are expected to live longer than elsewhere. In these zones, some people live to 90-100 years old. Youth & Earth explore this in their feature on ‘Blue Zones’ here. The brand is the largest supplier of NAD+ boosters in the United Kingdom and Europe - these are the natural fuel cells use to function. However, they become more depleted in our bodies as we age and “drop as much as 50% by we are 50.” Youth & Earth supplements target the nine hallmarks of ageing: Cellular senescence, stem cell exhaustion, poor intercellular communication, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, and mitochondrial dysfunction. The products target these by recreating the positive effects of a healthy lifestyle. Youth & Earth’s founder, Ed Van Harmelen, founded the company after learning that his NAD+ levels were dropping. He started learning about the principles of longevity pathways and researched the hallmarks of ageing back in 2017. He looked for supplements that address ageing at the cellular level, and found a gap in the market, so Youth & Earth was born. As they say, “Backed by science, rooted in rigorous research and, when combined with a healthy diet and lifestyle, are designed to slow down, stop or even reverse the ageing process.” All ingredients are researched, scientifically backed and have very high bioavailability. Products are all-natural, pure and vegan, with sublingual powders, delayed-release capsules, and liposomal formulas.

Preservage helps with cell health and antioxidant protection and is an all-natural supplement designed to optimise intestinal absorption of ingredients like Resveratrol (350%) and Curcumin (200%). The key three of quercetin, resveratrol and curcumin have scientific proof here. The full ingredients listed for Preservage are trans-resveratrol, curcumin, quercetin, bioperine (black pepper extract), rice flour, microcrystalline cellulose (plant fibre), and silicon dioxide.

The trans-resveratrol is commonly sourced from red wine, grapes, berries and chocolate (theirs comes from a surprising source - Japanese knotweed!) It is a natural polyphenol with many benefits, such as protecting the heart, helping the body fight disease, and lowering cholesterol. Trans-resveratrol versus resveratrol is more effective because it can cross the blood-brain barrier.

Curcumin is full of antioxidants and the principal curcuminoid of turmeric, a member of the ginger family, Zingiberaceae. It’s a natural anti-inflammatory compound and a potent antioxidant that can neutralise free radicals and may increase brain levels of BDNF protein which plays a role in memory and learning.

Quercetin mainly comes from onions, and is also found in many other fruits and vegetables like capers, asparagus, and apples, It is also rich in antioxidants. It’s thought to help protect the body from cardiovascular diseases and contains flavonoids with potent antioxidant properties.

Bioperine is a black pepper extra, which helps enhance nutrient absorption (particularly the curcumin)> It decreases inflammation, and stabilises blood sugar levels; and is also said to combat cancer cell growth, decrease inflammation, and boost brain function. The fillers are rice flour, which contains vitamin E and other nutrients such as calcium; Microcrystalline Cellulose which acts as an absorbent and emulsifier, and silicone dioxide, a natural compound and anti-caking agent that ensures full absorption.

Youth & Earth recommends taking two capsules of Preservage every morning on an empty stomach, which provides 200mg Trans-Resveratrol, 200mg Curcumin, 400mg Quercetin, and 20mg Bioperine. Taking the supplement daily allows it to naturally slow down ageing in the body, and it delays cellular ageing and boosts the longevity gene sirtuin. By the way, sirtuins are a family of 7 proteins, with each one playing a variety of roles. However, they all work in synergy to keep the body healthy and functioning efficiently. Again, best explained by Youth & Earth detail more about this here.

The Preservage is a potent polyphenol booster and mTOR inhibitor. Polyphenols are full of antioxidants that protect body tissue and help maintain healthy and youthful skin, whereas mTOR is a longevity pathway that helps slow the ageing process. How was it for us? We love the ingredients and what they offer, and are big fans of curcumin and trans-resveratrol already. Here the combination of trans-resveratrol, curcumin, quercetin and bioperine offers us pretty much all we need to increase our energy levels, aid anti-inflammatory issues, with the added bonus of slowing premature ageing - all in two daily capsules! Youth & Earth also recommends taking their NMN with Preservage for the ultimate anti-ageing effects - something we’ve yet to do. Start your anti-ageing journey today and purchase Preservage here 60 x 410mg capsules for £29.99 as a one time purchase, or subscribe and save 15% off.